Shikonin

Across CCLE and GDSC cell-line panels, response to Shikonin is significantly associated with the shRNA pathway dependency of multiple pathways, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible Shikonin response-associated pathways across cancer lineages are Negative regulation of G2/M transition of mitotic cell cycle, Negative regulation of cell cycle G2/M phase transition, and Pericentric heterochromatin formation, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Shikonin response versus Negative regulation of G2/M transition of mitotic cell cycle shRNA pathway dependency in LIVER (Pearson r = -0.73).

Shrna pathway dependency biomarkers of Shikonin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of G2/M transition of mitotic cell cycle →	-0.231	-0.933	.003	.018	3	7
LIVER	Negative regulation of cell cycle G2/M phase transition →	-0.238	-0.933	.003	.018	3	7
LUNG_SCLC	Pericentric heterochromatin formation →	-0.749	-0.785	.041	.008	3	7
URINARY_TRACT	Negative regulation of interleukin-6 production →	+1.285	+0.662	.016	.006	3	6
LIVER	Membrane depolarization during AV node cell action potential →	+1.383	+0.858	.020	.002	3	6
KIDNEY	Endoplasmic reticulum to cytosol transport →	-0.259	-0.674	.021	.029	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Shikonin response vs Negative regulation of G2/M transition of mitotic cell cycle — LIVER

Explore this scatter interactively →