Serdemetan

Across CCLE and GDSC cell-line panels, response to Serdemetan is significantly associated with the pathway activity of multiple pathways, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible Serdemetan response-associated pathways across cancer lineages are Negative regulation of macrophage chemotaxis, Regulation of cell-substrate junction organization, and Alpha-amino acid metabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Serdemetan response versus Negative regulation of macrophage chemotaxis pathway activity in BLOOD_Lymphoma (Pearson r = 0.33).

Pathway activity biomarkers of Serdemetan response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of macrophage chemotaxis →	+0.156	+0.392	.002	.005	3	9
BONE	Regulation of cell-substrate junction organization →	-0.216	-1.103	<.001	<.001	3	9
BONE	Alpha-amino acid metabolic process →	+0.121	+1.297	.017	.001	3	9
OVARY	rRNA metabolic process →	+0.112	+0.819	.002	.010	3	8
BONE	L-amino acid metabolic process →	+0.145	+1.264	.034	.002	3	8
BONE	Positive regulation of plasma membrane repair →	-0.213	-0.955	.002	.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Serdemetan response vs Negative regulation of macrophage chemotaxis — BLOOD_Lymphoma

Explore this scatter interactively →