Selumetinib

Across CCLE and GDSC cell-line panels, response to Selumetinib is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible Selumetinib response-associated pathways across cancer lineages are Regulation of cellular extravasation, Phosphatidylethanolamine biosynthetic process, and Aspartate transmembrane transport, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Selumetinib response versus Regulation of cellular extravasation protein-level pathway activity in LUNG_NSCLC_LUAD (Pearson r = -0.34).

Protein-level pathway activity biomarkers of Selumetinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of cellular extravasation →	-0.474	-0.653	.005	.002	3	8
LARGE_INTESTINE	Phosphatidylethanolamine biosynthetic process →	+1.223	+1.190	.001	<.001	3	7
LUNG_SCLC	Aspartate transmembrane transport →	+0.704	+0.356	.008	.036	2	8
BLOOD_Leukemia	Regulation of microvillus organization →	+0.187	+0.869	<.001	.001	3	7
LUNG_NSCLC_LUSC	Negative regulation of myeloid cell differentiation →	-0.111	-1.361	.015	<.001	3	7
STOMACH	Dentate gyrus development →	-0.861	-1.226	.031	.033	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Selumetinib response vs Regulation of cellular extravasation — LUNG_NSCLC_LUAD

Explore this scatter interactively →