Selisistat

Across CCLE and GDSC cell-line panels, response to Selisistat is significantly associated with the shRNA dependency of multiple gene dependencies, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Selisistat response-associated gene dependencies across cancer lineages are SUPT7L, GJB7, and DCLK1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Selisistat response versus SUPT7L shRNA dependency in LARGE_INTESTINE (Pearson r = 0.61).

Shrna dependency biomarkers of Selisistat response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SUPT7L →	+0.442	+0.269	.009	.044	3	8
PANCREAS	GJB7 →	+0.146	+0.338	.001	.002	3	8
LARGE_INTESTINE	DCLK1 →	+0.186	+0.417	<.001	<.001	3	7
BONE	MYT1L →	+0.176	+0.320	.030	.042	2	8
STOMACH	UQCRQ →	-0.456	-0.493	.002	.046	3	7
URINARY_TRACT	GRIN3A →	+0.189	+0.324	.006	.004	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Selisistat response vs SUPT7L — LARGE_INTESTINE

Explore this scatter interactively →