Selisistat

Across CCLE and GDSC cell-line panels, response to Selisistat is significantly associated with the mutation status of multiple genes, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Selisistat response-associated genes across cancer lineages are AHNAK2, NACA, and VWDE, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Selisistat response grouped by AHNAK2 status in PANCREAS.

Mutation status biomarkers of Selisistat response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	AHNAK2 →	+2.777	+0.220	.030	.047	3	4
SKIN	NACA →	+3.000	+0.287	.017	.006	3	3
BLOOD_Leukemia	VWDE →	+2.745	+0.239	.036	.004	3	3
LARGE_INTESTINE	ABCA2 →	+3.000	+0.207	.007	.005	3	3
LARGE_INTESTINE	COL7A1 →	+2.000	+0.186	.029	.012	3	3
LARGE_INTESTINE	HERC2 →	+1.378	+0.178	.004	.015	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Selisistat response by AHNAK2 status — PANCREAS

Explore this box plot interactively →