Schweinfurthin A

Across CCLE and GDSC cell-line panels, response to Schweinfurthin A is significantly associated with the pathway activity of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible Schweinfurthin A response-associated pathways across cancer lineages are Cellular response to unfolded protein, Response to unfolded protein, and Negative regulation of cellular response to growth factor stimulus, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Schweinfurthin A response versus Cellular response to unfolded protein pathway activity in STOMACH (Pearson r = -0.52).

Pathway activity biomarkers of Schweinfurthin A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cellular response to unfolded protein →	-0.089	-1.193	.002	<.001	3	11
OVARY	Response to unfolded protein →	-0.089	-0.847	.002	.018	2	10
BONE	Negative regulation of cellular response to growth factor stimulus →	-0.085	-1.662	.012	.004	3	9
OVARY	Epithelial cell-cell adhesion →	-0.339	-1.686	.001	.001	3	9
LUNG_NSCLC_LUSC	Calcium ion homeostasis →	-0.100	-1.502	.023	.017	3	9
OVARY	Endoplasmic reticulum unfolded protein response →	-0.098	-0.965	.005	.019	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Schweinfurthin A response vs Cellular response to unfolded protein — STOMACH

Explore this scatter interactively →