Saracatinib

Across CCLE and GDSC cell-line panels, response to Saracatinib is significantly associated with the protein abundance of multiple proteins, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible Saracatinib response-associated proteins across cancer lineages are PDLIM7, ADD3, and SLC12A4, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Saracatinib response versus PDLIM7 protein abundance in LUNG_NSCLC_LUAD (Pearson r = 0.65).

Protein abundance biomarkers of Saracatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDLIM7 →	+2.016	+1.463	.034	<.001	3	7
SKIN	ADD3 →	+0.929	+0.474	.037	.023	3	5
LARGE_INTESTINE	SLC12A4 →	+1.553	+0.916	.039	.006	3	5
LUNG_SCLC	RCC1L →	-0.577	-0.247	.007	.023	3	5
OESOPHAGUS	PWWP2A →	-0.815	-0.881	.006	.028	3	5
BLOOD_Lymphoma	HIBCH →	-0.629	-0.290	.021	.013	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Saracatinib response vs PDLIM7 — LUNG_NSCLC_LUAD

Explore this scatter interactively →