Sapitinib

Across CCLE and GDSC cell-line panels, response to Sapitinib is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible Sapitinib response-associated gene dependencies across cancer lineages are MEST, EGFR, and CSMD3, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Sapitinib response versus MEST shRNA dependency in LUNG_NSCLC_LUSC (Pearson r = -0.65).

Shrna dependency biomarkers of Sapitinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MEST →	-0.284	-1.720	.001	<.001	3	7
STOMACH	EGFR →	+0.623	+1.255	.001	.003	3	7
BONE	CSMD3 →	-0.399	-0.350	.004	.032	3	7
LUNG_SCLC	STK32C →	-0.208	-0.443	.005	.002	3	7
PANCREAS	PSMB5 →	-0.700	-0.625	.001	.001	3	6
SKIN	ELAPOR1 →	-0.150	-0.391	.040	.004	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Sapitinib response vs MEST — LUNG_NSCLC_LUSC

Explore this scatter interactively →