Sapitinib

Across CCLE and GDSC cell-line panels, response to Sapitinib is significantly associated with the protein abundance of multiple proteins, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Sapitinib response-associated proteins across cancer lineages are JUP, CUX1, and CARS1, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Sapitinib response versus JUP protein abundance in PANCREAS (Pearson r = 0.44).

Protein abundance biomarkers of Sapitinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	JUP →	+1.780	+0.609	.003	.007	3	9
BLOOD_Lymphoma	CUX1 →	+0.854	+0.544	.004	.001	3	8
PANCREAS	CARS1 →	-1.083	-0.764	.004	.001	3	8
OESOPHAGUS	CSNK1A1 →	+1.119	+0.942	.003	.013	3	8
OVARY	SLMAP →	+0.613	+0.716	<.001	.002	3	8
LUNG_NSCLC_LUSC	HDHD3 →	+1.286	+1.331	.017	.015	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Sapitinib response vs JUP — PANCREAS

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