Salubrinal

Across CCLE and GDSC cell-line panels, response to Salubrinal is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Salubrinal response-associated gene dependencies across cancer lineages are ZNF180, ATP6AP2, and NMUR1, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Salubrinal response versus ZNF180 shRNA dependency in LUNG_SCLC (Pearson r = 0.57).

Shrna dependency biomarkers of Salubrinal response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF180 →	+0.165	+0.496	.039	.001	3	5
OESOPHAGUS	ATP6AP2 →	-0.334	-0.689	.005	.029	3	5
LUNG_NSCLC_LUAD	NMUR1 →	+0.134	+0.608	.004	.010	3	4
LUNG_NSCLC_LUAD	INSM1 →	-0.240	-0.794	.037	.006	3	4
LUNG_SCLC	HOXD10 →	+0.467	+0.547	<.001	.003	3	4
LUNG_SCLC	WDR36 →	+0.306	+0.383	.026	.042	2	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Salubrinal response vs ZNF180 — LUNG_SCLC

Explore this scatter interactively →