Salubrinal

Across CCLE and GDSC cell-line panels, response to Salubrinal is significantly associated with the mutation status of multiple genes, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Salubrinal response-associated genes across cancer lineages are RYR3, BIRC6, and GIGYF1, each associated with drug response in up to 2 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Salubrinal response grouped by RYR3 status in LUNG_SCLC.

Mutation status biomarkers of Salubrinal response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RYR3 →	+2.736	+0.257	.019	.048	3	2
BLOOD_Lymphoma	BIRC6 →	+2.999	+0.385	.024	.012	3	1
BLOOD_Lymphoma	GIGYF1 →	+2.885	+0.338	.018	.029	3	1
BLOOD_Lymphoma	ADAMTSL3 →	+2.662	+0.310	.042	.046	3	1
BLOOD_Lymphoma	TNRC18 →	+2.807	+0.277	.032	.039	3	1
BLOOD_Lymphoma	EPB41L3 →	+2.662	+0.338	.042	.029	3	1

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Salubrinal response by RYR3 status — LUNG_SCLC

Explore this box plot interactively →