Sabutoclax

Across CCLE and GDSC cell-line panels, response to Sabutoclax is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Sabutoclax response-associated genes across cancer lineages are JMJD1C, SPEG, and CSMD2, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Sabutoclax response grouped by JMJD1C status in LARGE_INTESTINE.

Mutation status biomarkers of Sabutoclax response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JMJD1C →	+1.999	+0.384	.036	.013	3	3
BLOOD_Leukemia	SPEG →	+3.169	+0.368	.013	.015	2	4
LARGE_INTESTINE	CSMD2 →	+1.263	+0.325	.031	.031	3	3
LARGE_INTESTINE	MUC4 →	+0.769	+0.404	.031	.009	3	3
BLOOD_Leukemia	ANK3 →	+2.807	+0.323	.042	.018	3	3
LUNG_NSCLC_LUAD	SPTBN5 →	+1.914	+0.376	.046	.046	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Sabutoclax response by JMJD1C status — LARGE_INTESTINE

Explore this box plot interactively →