SU11274

Across CCLE and GDSC cell-line panels, response to SU11274 is significantly associated with the pathway activity of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible SU11274 response-associated pathways across cancer lineages are Subtelomeric heterochromatin formation, Regulation of T cell proliferation, and Mitochondrial DNA repair, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SU11274 response versus Subtelomeric heterochromatin formation pathway activity in LUNG_NSCLC_LUSC (Pearson r = 0.35).

Pathway activity biomarkers of SU11274 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Subtelomeric heterochromatin formation →	+0.100	+0.449	.048	.027	3	9
OVARY	Regulation of T cell proliferation →	-0.150	-0.763	.006	.006	3	9
LUNG_NSCLC_LUSC	Mitochondrial DNA repair →	+0.199	+0.612	.007	.026	3	9
LUNG_NSCLC_LUSC	Positive regulation of transcription by RNA polymerase I →	+0.146	+0.634	.004	.044	3	9
URINARY_TRACT	Endothelial cell differentiation →	-0.137	-0.513	<.001	.006	3	9
LARGE_INTESTINE	Regulation of CD4-positive, alpha-beta T cell activation →	-0.063	-0.635	.008	.011	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SU11274 response vs Subtelomeric heterochromatin formation — LUNG_NSCLC_LUSC

Explore this scatter interactively →