STF-62247

Across CCLE and GDSC cell-line panels, response to STF-62247 is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible STF-62247 response-associated pathways across cancer lineages are Glycerol catabolic process, Cranial nerve morphogenesis, and snRNA metabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, STF-62247 response versus Glycerol catabolic process protein-level pathway activity in BONE (Pearson r = -0.42).

Protein-level pathway activity biomarkers of STF-62247 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Glycerol catabolic process →	-0.184	-0.522	.008	.004	3	8
KIDNEY	Cranial nerve morphogenesis →	+1.234	+0.717	.004	.003	3	7
URINARY_TRACT	snRNA metabolic process →	+1.389	+0.410	.010	.012	3	7
BONE	Regulation of protein localization to plasma membrane →	-0.322	-0.567	.001	.002	3	7
BONE	Regulation of protein localization to cell periphery →	-0.213	-0.483	.008	.001	3	7
OVARY	Response to methionine →	+1.412	+0.481	<.001	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STF-62247 response vs Glycerol catabolic process — BONE

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