SNX-2112

Across CCLE and GDSC cell-line panels, response to SNX-2112 is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible SNX-2112 response-associated pathways across cancer lineages are Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, Stress granule assembly, and Regulation of translational initiation, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SNX-2112 response versus Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay protein-level pathway activity in BONE (Pearson r = 0.55).

Protein-level pathway activity biomarkers of SNX-2112 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.258	+1.512	.001	.004	3	9
BONE	Stress granule assembly →	+0.481	+1.596	<.001	.003	3	8
LARGE_INTESTINE	Regulation of translational initiation →	+0.237	+0.932	.002	.014	3	8
OESOPHAGUS	Regulation of morphogenesis of a branching structure →	-0.584	-1.559	.002	<.001	3	8
BONE	Trabecula morphogenesis →	+0.648	+0.709	.008	.048	3	8
LARGE_INTESTINE	Regulation of translation at postsynapse →	+0.197	+0.859	<.001	.004	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX-2112 response vs Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay — BONE

Explore this scatter interactively →