SN-38

Across CCLE and GDSC cell-line panels, response to SN-38 is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible SN-38 response-associated proteins across cancer lineages are MSH6, p62 Lck ligand, and Snail, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SN-38 response versus MSH6 total protein in BONE (Pearson r = 0.51).

Total protein biomarkers of SN-38 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MSH6 →	+0.746	+1.802	.047	.003	3	7
BONE	p62 Lck ligand →	-1.662	-1.861	<.001	<.001	3	7
BONE	Snail →	-0.805	-1.737	.010	.023	3	6
BONE	VEGFR2 →	-1.440	-1.665	.012	.004	3	5
UPPER_AERODIGESTIVE_TRACT	p70-S6K →	+0.703	+1.104	.003	.010	3	5
BLOOD_Myeloma	ATM →	+1.525	+0.887	.016	.037	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SN-38 response vs MSH6 — BONE

Explore this scatter interactively →