SN-38

Across CCLE and GDSC cell-line panels, response to SN-38 is significantly associated with the shRNA pathway dependency of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible SN-38 response-associated pathways across cancer lineages are Adherens junction maintenance, Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway, and Regulation of neutrophil chemotaxis, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SN-38 response versus Adherens junction maintenance shRNA pathway dependency in STOMACH (Pearson r = -0.65).

Shrna pathway dependency biomarkers of SN-38 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Adherens junction maintenance →	-1.165	-1.682	.010	.004	3	8
LUNG_NSCLC_LUAD	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway →	+0.554	+0.530	.007	.015	3	8
BLOOD_Myeloma	Regulation of neutrophil chemotaxis →	-1.767	-0.915	.015	.048	3	7
LIVER	Negative regulation of synaptic transmission, GABAergic →	+1.758	+0.973	<.001	.012	3	7
SOFT_TISSUE	Positive regulation of granulocyte chemotaxis →	-1.479	-0.562	.002	.021	2	8
SOFT_TISSUE	Positive regulation of neutrophil chemotaxis →	-1.581	-0.562	.002	.021	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SN-38 response vs Adherens junction maintenance — STOMACH

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