SGC0946

Across CCLE and GDSC cell-line panels, response to SGC0946 is significantly associated with the protein abundance of multiple proteins, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible SGC0946 response-associated proteins across cancer lineages are SLC34A2, CAST, and FAM184B, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SGC0946 response versus SLC34A2 protein abundance in PANCREAS (Pearson r = -0.41).

Protein abundance biomarkers of SGC0946 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC34A2 →	-1.148	-0.589	<.001	.017	3	9
BLOOD_Lymphoma	CAST →	-0.651	-0.205	.007	.004	3	9
LARGE_INTESTINE	FAM184B →	-0.829	-0.285	.004	.004	3	9
BONE	AP2B1 →	-0.489	-0.207	.020	.024	3	9
URINARY_TRACT	ZNF671 →	-2.086	-0.383	.004	.016	3	8
URINARY_TRACT	DHX15 →	+0.586	+0.421	.001	.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGC0946 response vs SLC34A2 — PANCREAS

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