SGC-CBP30

Across CCLE and GDSC cell-line panels, response to SGC-CBP30 is significantly associated with the protein abundance of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible SGC-CBP30 response-associated proteins across cancer lineages are LMNA, EEF1E1, and OGDH, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SGC-CBP30 response versus LMNA protein abundance in OVARY (Pearson r = -0.42).

Protein abundance biomarkers of SGC-CBP30 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LMNA →	-1.436	-0.288	.031	.021	3	8
LARGE_INTESTINE	EEF1E1 →	+0.754	+0.492	.008	.001	3	8
LIVER	OGDH →	-0.733	-0.639	.008	<.001	3	7
LUNG_SCLC	RRBP1 →	-1.175	-0.441	.035	.049	3	6
LUNG_SCLC	OS9 →	-0.958	-0.519	.049	.017	2	7
STOMACH	ENDOD1 →	-2.109	-0.481	.006	.012	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGC-CBP30 response vs LMNA — OVARY

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