SCH772984

Across CCLE and GDSC cell-line panels, response to SCH772984 is significantly associated with the shRNA dependency of multiple gene dependencies, with BONE cell lines showing a particularly strong set of associations.

The most reproducible SCH772984 response-associated gene dependencies across cancer lineages are EP300, NF2, and E2F4, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SCH772984 response versus EP300 shRNA dependency in BONE (Pearson r = 0.65).

Shrna dependency biomarkers of SCH772984 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	EP300 →	+0.350	+0.906	.020	.029	2	8
OVARY	NF2 →	+0.188	+0.678	.027	.038	3	7
UPPER_AERODIGESTIVE_TRACT	E2F4 →	+0.400	+0.650	.021	.011	3	7
OESOPHAGUS	SLC35E1 →	-0.159	-0.718	.018	.020	3	7
BLOOD_Leukemia	TUBGCP2 →	-0.493	-1.290	.013	.010	3	7
KIDNEY	IRAK1 →	-0.317	-0.491	.004	.004	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCH772984 response vs EP300 — BONE

Explore this scatter interactively →