SCH772984

Across CCLE and GDSC cell-line panels, response to SCH772984 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible SCH772984 response-associated genes across cancer lineages are MGAT5, COL12A1, and LRBA, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, SCH772984 response grouped by MGAT5 status in LARGE_INTESTINE.

Mutation status biomarkers of SCH772984 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MGAT5 →	-2.807	-0.597	.027	.008	3	3
BLOOD_Leukemia	COL12A1 →	-2.968	-0.582	.011	.007	3	3
LARGE_INTESTINE	LRBA →	-1.999	-0.467	.036	.027	3	3
LUNG_NSCLC_LUAD	ANKRD17 →	-3.169	-0.708	.012	.004	3	2
LUNG_SCLC	HYDIN →	+3.169	+0.385	.010	.010	3	2
BLOOD_Leukemia	CSMD3 →	-1.549	-0.458	.006	.013	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCH772984 response by MGAT5 status — LARGE_INTESTINE

Explore this box plot interactively →