SB590885

Across CCLE and GDSC cell-line panels, response to SB590885 is significantly associated with the shRNA pathway dependency of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible SB590885 response-associated pathways across cancer lineages are Heat acclimation, Cellular heat acclimation, and MHC class I protein complex assembly, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SB590885 response versus Heat acclimation shRNA pathway dependency in LARGE_INTESTINE (Pearson r = -0.53).

Shrna pathway dependency biomarkers of SB590885 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Heat acclimation →	-1.254	-0.873	.002	.009	3	7
LARGE_INTESTINE	Cellular heat acclimation →	-1.254	-0.873	.002	.009	3	7
STOMACH	MHC class I protein complex assembly →	-1.210	-0.471	.009	.012	3	7
STOMACH	Peptide antigen assembly with MHC class I protein complex →	-1.210	-0.471	.009	.012	3	7
BLOOD_Leukemia	Regulation of cold-induced thermogenesis →	+0.171	+0.400	.039	.015	3	7
PANCREAS	Regulation of type I interferon-mediated signaling pathway →	-0.705	-0.554	.020	.004	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SB590885 response vs Heat acclimation — LARGE_INTESTINE

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