SB505124

Across CCLE and GDSC cell-line panels, response to SB505124 is significantly associated with the protein abundance of multiple proteins, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible SB505124 response-associated proteins across cancer lineages are UBE2I, ARMCX4, and NDUFA7, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SB505124 response versus UBE2I protein abundance in KIDNEY (Pearson r = 0.39).

Protein abundance biomarkers of SB505124 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	UBE2I →	+0.487	+0.451	.013	.041	3	6
BLOOD_Lymphoma	ARMCX4 →	-1.227	-0.789	.011	.044	3	5
KIDNEY	NDUFA7 →	-1.442	-0.553	.021	.005	3	5
UPPER_AERODIGESTIVE_TRACT	CKAP5 →	+1.017	+0.720	.004	.009	3	5
UPPER_AERODIGESTIVE_TRACT	GCN1 →	+1.635	+0.790	<.001	.006	3	5
LUNG_NSCLC_LUAD	UQCC2 →	-1.026	-1.320	.029	.019	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SB505124 response vs UBE2I — KIDNEY

Explore this scatter interactively →