SB216763

Across CCLE and GDSC cell-line panels, response to SB216763 is significantly associated with the protein abundance of multiple proteins, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible SB216763 response-associated proteins across cancer lineages are HAGH, ZNF671, and C1orf131, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, SB216763 response versus HAGH protein abundance in LUNG_NSCLC_LUSC (Pearson r = -0.38).

Protein abundance biomarkers of SB216763 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HAGH →	-1.404	-0.327	.049	.017	3	9
STOMACH	ZNF671 →	-1.660	-0.560	.032	.003	3	9
BREAST	C1orf131 →	+1.047	+0.664	.041	.020	3	9
STOMACH	EIF3F →	+0.868	+0.315	.019	.028	3	9
LUNG_SCLC	MLEC →	-0.797	-0.269	.013	.048	3	8
SOFT_TISSUE	LARS1 →	+0.636	+0.367	.017	.028	2	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SB216763 response vs HAGH — LUNG_NSCLC_LUSC

Explore this scatter interactively →