S-Trityl-L-cysteine

Across CCLE and GDSC cell-line panels, response to S-Trityl-L-cysteine is significantly associated with the pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible S-Trityl-L-cysteine response-associated pathways across cancer lineages are Valine metabolic process, L-valine catabolic process, and Ral protein signal transduction, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, S-Trityl-L-cysteine response versus Valine metabolic process pathway activity in BREAST (Pearson r = -0.57).

Pathway activity biomarkers of S-Trityl-L-cysteine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Valine metabolic process →	-0.210	-0.903	.007	.006	3	6
BREAST	L-valine catabolic process →	-0.210	-0.903	.007	.006	3	6
OESOPHAGUS	Ral protein signal transduction →	-0.151	-0.396	.048	.048	3	6
CNS	Gamma-delta T cell activation →	+0.198	+1.139	.001	.046	3	5
SKIN	G protein-coupled purinergic nucleotide receptor signaling pathway →	+1.858	+1.399	<.001	.001	3	5
OESOPHAGUS	Cellular response to type I interferon →	-0.134	-0.446	.006	.041	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S-Trityl-L-cysteine response vs Valine metabolic process — BREAST

Explore this scatter interactively →