Rucaparib

Across CCLE and GDSC cell-line panels, response to Rucaparib is significantly associated with the pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Rucaparib response-associated pathways across cancer lineages are Negative regulation of translational elongation, Ribosomal large subunit assembly, and Mitochondrial ribosome assembly, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Rucaparib response versus Negative regulation of translational elongation pathway activity in LUNG_SCLC (Pearson r = 0.44).

Pathway activity biomarkers of Rucaparib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of translational elongation →	+0.119	+0.694	.023	.002	3	8
BONE	Ribosomal large subunit assembly →	+0.234	+0.860	.001	.005	3	7
BONE	Mitochondrial ribosome assembly →	+0.190	+0.940	.002	.003	3	7
UPPER_AERODIGESTIVE_TRACT	Aromatic amino acid metabolic process →	+0.128	+0.274	.024	.018	3	7
SOFT_TISSUE	Regulation of calcium ion transport into cytosol →	-0.264	-0.294	.003	.028	2	8
KIDNEY	Positive regulation of myeloid cell apoptotic process →	-0.242	-0.609	.003	.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Rucaparib response vs Negative regulation of translational elongation — LUNG_SCLC

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