Rucaparib

Across CCLE and GDSC cell-line panels, response to Rucaparib is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Rucaparib response-associated pathways across cancer lineages are Regulation of plasma membrane repair, Cellular extravasation, and rRNA 5'-end processing, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Rucaparib response versus Regulation of plasma membrane repair protein-level pathway activity in BONE (Pearson r = -0.53).

Protein-level pathway activity biomarkers of Rucaparib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of plasma membrane repair →	-0.261	-0.596	<.001	<.001	3	9
STOMACH	Cellular extravasation →	-0.297	-0.685	.036	.005	3	9
URINARY_TRACT	rRNA 5'-end processing →	+1.842	+0.392	.003	.024	2	9
URINARY_TRACT	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+1.842	+0.392	.003	.024	2	9
LUNG_NSCLC_LUAD	Epithelial cell development →	-0.154	-0.492	.001	<.001	3	8
SOFT_TISSUE	Single fertilization →	-0.248	-0.387	.001	.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Rucaparib response vs Regulation of plasma membrane repair — BONE

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