Refametinib

Across CCLE and GDSC cell-line panels, response to Refametinib is significantly associated with the pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Refametinib response-associated pathways across cancer lineages are Skin development, Negative regulation of actin filament polymerization, and Positive regulation of transmission of nerve impulse, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Refametinib response versus Skin development pathway activity in BREAST (Pearson r = 0.37).

Pathway activity biomarkers of Refametinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Skin development →	+0.124	+0.689	.003	.003	3	10
LIVER	Negative regulation of actin filament polymerization →	+0.130	+0.805	.002	.007	3	10
LUNG_NSCLC_LUSC	Positive regulation of transmission of nerve impulse →	+2.110	+1.033	<.001	.001	3	9
KIDNEY	Cell-matrix adhesion →	+0.135	+0.754	.014	.039	3	9
LIVER	Regulation of response to wounding →	+0.136	+0.754	.032	.012	3	9
LUNG_NSCLC_LUSC	Formation of primary germ layer →	+0.132	+1.033	.002	.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Refametinib response vs Skin development — BREAST

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