RAF_9304

Across CCLE and GDSC cell-line panels, response to RAF_9304 is significantly associated with the total protein of multiple proteins, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible RAF_9304 response-associated proteins across cancer lineages are TSC1, PDK1_pS241, and PDK1, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, RAF_9304 response versus TSC1 total protein in BLOOD_Leukemia (Pearson r = -0.40).

Total protein biomarkers of RAF_9304 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSC1 →	-0.447	-0.896	.013	.012	3	6
BLOOD_Myeloma	PDK1_pS241 →	-0.557	-0.527	.001	.047	3	6
BLOOD_Myeloma	PDK1 →	-0.480	-0.832	.004	.031	3	6
LUNG_NSCLC_LUSC	YAP_pS127 →	+1.152	+0.636	.010	.030	3	6
LARGE_INTESTINE	FRA1 →	+0.851	+0.645	.002	.002	3	6
LUNG_SCLC	c-Myc →	+1.121	+0.586	<.001	<.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAF_9304 response vs TSC1 — BLOOD_Leukemia

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