RAF_9304

Across CCLE and GDSC cell-line panels, response to RAF_9304 is significantly associated with the pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible RAF_9304 response-associated pathways across cancer lineages are Negative regulation of signal transduction in absence of ligand, Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, and Regulation of response to cytokine stimulus, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, RAF_9304 response versus Negative regulation of signal transduction in absence of ligand pathway activity in BREAST (Pearson r = -0.49).

Pathway activity biomarkers of RAF_9304 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of signal transduction in absence of ligand →	-0.116	-0.505	.004	.006	3	8
BREAST	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand →	-0.116	-0.505	.004	.006	3	8
STOMACH	Regulation of response to cytokine stimulus →	-0.049	-0.492	.004	.007	3	8
URINARY_TRACT	Muscle system process →	+0.060	+0.555	.030	.032	3	8
BREAST	Sneeze reflex →	+1.321	+0.526	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Peptidyl-tyrosine dephosphorylation →	+0.122	+0.598	.006	.020	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAF_9304 response vs Negative regulation of signal transduction in absence of ligand — BREAST

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