Quizartinib

Across CCLE and GDSC cell-line panels, response to Quizartinib is significantly associated with the shRNA pathway dependency of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Quizartinib response-associated pathways across cancer lineages are UDP-N-acetylglucosamine biosynthetic process, Negative regulation of cellular response to transforming growth factor beta stimulus, and Secondary metabolite biosynthetic process, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Quizartinib response versus UDP-N-acetylglucosamine biosynthetic process shRNA pathway dependency in BONE (Pearson r = -0.96).

Shrna pathway dependency biomarkers of Quizartinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	UDP-N-acetylglucosamine biosynthetic process →	-2.011	-0.804	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cellular response to transforming growth factor beta stimulus →	-1.205	-0.145	.011	.036	3	7
OESOPHAGUS	Secondary metabolite biosynthetic process →	+1.193	+0.195	.003	.007	3	7
KIDNEY	Synaptic vesicle membrane organization →	+1.750	+0.603	.024	.012	3	6
SKIN	Negative regulation of synaptic transmission, glutamatergic →	+1.032	+0.362	.021	.017	3	6
OVARY	Regulation of neuron maturation →	+1.186	+0.373	.010	.015	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Quizartinib response vs UDP-N-acetylglucosamine biosynthetic process — BONE

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