QL-XII-61

Across CCLE and GDSC cell-line panels, response to QL-XII-61 is significantly associated with the total protein of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible QL-XII-61 response-associated proteins across cancer lineages are eIF4G, FRA1, and Cyclin-E2, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, QL-XII-61 response versus eIF4G total protein in OVARY (Pearson r = 0.38).

Total protein biomarkers of QL-XII-61 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	eIF4G →	+0.674	+0.640	.020	.025	3	6
LUNG_SCLC	FRA1 →	-1.111	-1.019	.001	.010	3	5
PANCREAS	Cyclin-E2 →	+0.954	+0.837	.025	.004	3	5
OESOPHAGUS	p27_pT198 →	-0.437	-0.505	.015	.009	3	5
BREAST	PCNA →	+0.488	+0.520	.042	.008	3	5
BREAST	Annexin_VII →	-0.381	-0.551	.004	.009	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QL-XII-61 response vs eIF4G — OVARY

Explore this scatter interactively →