QL-XII-61

Across CCLE and GDSC cell-line panels, response to QL-XII-61 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible QL-XII-61 response-associated genes across cancer lineages are CSMD3, MYH6, and DMD, each associated with drug response in up to 2 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, QL-XII-61 response grouped by CSMD3 status in LARGE_INTESTINE.

Mutation status biomarkers of QL-XII-61 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSMD3 →	+1.977	+0.350	.015	.015	3	2
LARGE_INTESTINE	MYH6 →	+2.491	+0.340	.049	.024	3	2
LARGE_INTESTINE	DMD →	+1.977	+0.350	.015	.015	3	2
LARGE_INTESTINE	FAT2 →	+1.392	+0.339	.049	.020	3	2
LARGE_INTESTINE	DNAH11 →	+2.491	+0.334	.049	.023	3	2
LARGE_INTESTINE	HERC2 →	+1.465	+0.419	.004	.003	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QL-XII-61 response by CSMD3 status — LARGE_INTESTINE

Explore this box plot interactively →