QL-XII-47

Across CCLE and GDSC cell-line panels, response to QL-XII-47 is significantly associated with the total protein of multiple proteins, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible QL-XII-47 response-associated proteins across cancer lineages are Rb, Bcl-xL, and C-Raf(MP05-739), each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, QL-XII-47 response versus Rb total protein in BLOOD_Lymphoma (Pearson r = 0.40).

Total protein biomarkers of QL-XII-47 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Rb →	+0.456	+0.628	.040	.020	3	7
STOMACH	Bcl-xL →	-0.446	-1.164	.017	.003	2	7
SKIN	C-Raf(MP05-739) →	+0.255	+0.729	.005	<.001	3	6
OVARY	Cyclin-D1 →	-0.383	-0.706	.007	.015	3	6
KIDNEY	XBP1 →	+0.305	+0.865	.019	.022	3	6
STOMACH	Smac →	-0.729	-1.318	.008	.006	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QL-XII-47 response vs Rb — BLOOD_Lymphoma

Explore this scatter interactively →