QL-XII-47

Across CCLE and GDSC cell-line panels, response to QL-XII-47 is significantly associated with the mutation status of multiple genes, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible QL-XII-47 response-associated genes across cancer lineages are DNAH6, FLG2, and PIK3C2G, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, QL-XII-47 response grouped by DNAH6 status in BLOOD_Lymphoma.

Mutation status biomarkers of QL-XII-47 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DNAH6 →	-2.169	-0.524	.039	.004	3	3
OESOPHAGUS	FLG2 →	-2.917	-0.751	.017	.014	3	3
BLOOD_Leukemia	PIK3C2G →	-2.807	-0.359	.047	.012	3	3
BLOOD_Lymphoma	HIVEP3 →	-2.807	-0.396	.040	.042	3	2
LUNG_NSCLC_LUAD	LIG1 →	+2.856	+0.520	.025	.048	3	2
LUNG_NSCLC_LUAD	BIRC6 →	-2.169	-0.467	.030	.023	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

QL-XII-47 response by DNAH6 status — BLOOD_Lymphoma

Explore this box plot interactively →