Podophyllotoxin bromide

Across CCLE and GDSC cell-line panels, response to Podophyllotoxin bromide is significantly associated with the total protein of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Podophyllotoxin bromide response-associated proteins across cancer lineages are 4E-BP1, ASNS, and c-Myc, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Podophyllotoxin bromide response versus 4E-BP1 total protein in OVARY (Pearson r = 0.71).

Total protein biomarkers of Podophyllotoxin bromide response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	4E-BP1 →	+0.974	+0.864	<.001	<.001	3	7
LUNG_SCLC	ASNS →	+0.887	+0.781	.047	.022	3	6
OVARY	c-Myc →	+0.412	+0.489	.002	.022	3	6
LUNG_SCLC	INPP4B →	-0.658	-0.724	.001	.011	3	5
LARGE_INTESTINE	SETD2 →	-0.633	-0.903	.009	<.001	3	5
BONE	S6_pS235_S236 →	-2.275	-0.683	<.001	.035	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Podophyllotoxin bromide response vs 4E-BP1 — OVARY

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