Pictilisib

Across CCLE and GDSC cell-line panels, response to Pictilisib is significantly associated with the total protein of multiple proteins, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible Pictilisib response-associated proteins across cancer lineages are FOXO3a, Gab2, and Chk2_pT68, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Pictilisib response versus FOXO3a total protein in LIVER (Pearson r = 0.77).

Total protein biomarkers of Pictilisib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FOXO3a →	+0.475	+0.494	.002	.017	3	7
BLOOD_Lymphoma	Gab2 →	-1.202	-0.758	.019	.004	3	5
LUNG_NSCLC_LUSC	Chk2_pT68 →	+0.584	+0.780	.039	.033	3	5
LUNG_SCLC	AMPK_alpha →	-0.434	-0.711	.019	.009	3	5
BREAST	PEA-15 →	-0.364	-0.655	.010	.023	3	5
LUNG_NSCLC_LUAD	TSC1 →	-0.339	-0.436	.047	.018	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Pictilisib response vs FOXO3a — LIVER

Explore this scatter interactively →