Phenformin

Across CCLE and GDSC cell-line panels, response to Phenformin is significantly associated with the RNA expression of multiple genes, with CNS cell lines showing a particularly strong set of associations.

The most reproducible Phenformin response-associated genes across cancer lineages are HECW2, THOC1, and B4GALT5, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Phenformin response versus HECW2 RNA expression in CNS (Pearson r = -0.55).

Rna expression biomarkers of Phenformin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HECW2 →	-1.193	-0.660	<.001	<.001	3	8
SOFT_TISSUE	THOC1 →	+0.728	+1.038	.012	.011	3	8
LUNG_NSCLC_LUSC	B4GALT5 →	-0.969	-0.687	.019	.025	3	8
LARGE_INTESTINE	NCEH1 →	-0.894	-1.087	.011	.005	3	8
BLOOD_Lymphoma	SDC4 →	-2.126	-0.847	.002	.014	3	8
STOMACH	TGFA →	-2.087	-0.755	.049	.033	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Phenformin response vs HECW2 — CNS

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