Palbociclib

Across CCLE and GDSC cell-line panels, response to Palbociclib is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Palbociclib response-associated proteins across cancer lineages are 4E-BP1, MSH6, and eEF2K, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Palbociclib response versus 4E-BP1 total protein in BONE (Pearson r = 0.60).

Total protein biomarkers of Palbociclib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	4E-BP1 →	+0.991	+0.842	.020	.003	3	8
PANCREAS	MSH6 →	+0.491	+0.655	.011	.001	3	8
KIDNEY	eEF2K →	+0.654	+0.807	.049	.012	3	8
BONE	VEGFR2 →	-1.809	-0.735	.017	.008	3	7
LARGE_INTESTINE	alpha-Catenin →	-0.627	-0.627	<.001	<.001	3	7
BONE	ER-alpha_pS118 →	+0.266	+0.859	.004	.002	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Palbociclib response vs 4E-BP1 — BONE

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