Paclitaxel

Across CCLE and GDSC cell-line panels, response to Paclitaxel is significantly associated with the shRNA pathway dependency of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Paclitaxel response-associated pathways across cancer lineages are Vacuolar transport, Membrane fission, and Regulation of macrophage chemotaxis, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Paclitaxel response versus Vacuolar transport shRNA pathway dependency in PANCREAS (Pearson r = -0.66).

Shrna pathway dependency biomarkers of Paclitaxel response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Vacuolar transport →	-0.242	-1.044	<.001	<.001	3	8
STOMACH	Membrane fission →	-0.232	-0.768	.004	.004	3	8
CNS	Regulation of macrophage chemotaxis →	+0.900	+0.712	.019	.040	3	7
OVARY	Regulation of coagulation →	+1.176	+1.263	.008	.017	3	7
LUNG_SCLC	Sympathetic ganglion development →	-1.209	-0.976	.002	.001	3	7
SKIN	Regulation of thymocyte apoptotic process →	+1.424	+0.586	.001	.015	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Paclitaxel response vs Vacuolar transport — PANCREAS

Explore this scatter interactively →