PRT062607

Across CCLE and GDSC cell-line panels, response to PRT062607 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible PRT062607 response-associated pathways across cancer lineages are Regulation of NK T cell activation, Secondary piRNA processing, and GPI anchored protein biosynthesis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PRT062607 response versus Regulation of NK T cell activation shRNA pathway dependency in BLOOD_Lymphoma (Pearson r = -0.75).

Shrna pathway dependency biomarkers of PRT062607 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of NK T cell activation →	-1.673	-0.575	.007	.032	3	7
SKIN	Secondary piRNA processing →	+1.364	+0.696	.027	.015	3	6
SOFT_TISSUE	GPI anchored protein biosynthesis →	+2.191	+0.973	<.001	.014	3	6
URINARY_TRACT	Regulation of transforming growth factor beta production →	+1.727	+0.815	<.001	.017	3	6
BONE	Positive regulation of natural killer cell mediated immune response to tumor cell →	-2.219	-0.599	.001	.013	3	6
KIDNEY	Regulation of platelet-derived growth factor receptor-alpha signaling pathway →	-1.880	-1.003	<.001	.049	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRT062607 response vs Regulation of NK T cell activation — BLOOD_Lymphoma

Explore this scatter interactively →