PRIMA-1MET

Across CCLE and GDSC cell-line panels, response to PRIMA-1MET is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible PRIMA-1MET response-associated pathways across cancer lineages are Autophagy of peroxisome, Pexophagy, and Neuron projection extension, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PRIMA-1MET response versus Autophagy of peroxisome protein-level pathway activity in LUNG_NSCLC_LUSC (Pearson r = -0.66).

Protein-level pathway activity biomarkers of PRIMA-1MET response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Autophagy of peroxisome →	-1.250	-0.596	.019	.003	3	8
LUNG_NSCLC_LUSC	Pexophagy →	-1.250	-0.596	.019	.003	3	8
SOFT_TISSUE	Neuron projection extension →	-0.327	-0.941	.005	.010	3	8
PANCREAS	Regulatory ncRNA-mediated post-transcriptional gene silencing →	+0.229	+0.759	.013	.023	3	8
LUNG_NSCLC_LUSC	Aminophospholipid transport →	-1.487	-0.839	<.001	.040	3	7
PANCREAS	Import into nucleus →	+0.215	+0.835	.009	.039	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRIMA-1MET response vs Autophagy of peroxisome — LUNG_NSCLC_LUSC

Explore this scatter interactively →