PLK_6522

Across CCLE and GDSC cell-line panels, response to PLK_6522 is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible PLK_6522 response-associated genes across cancer lineages are MUC5B, CSMD2, and PDE4DIP, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, PLK_6522 response grouped by MUC5B status in LARGE_INTESTINE.

Mutation status biomarkers of PLK_6522 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MUC5B →	+1.295	+0.557	.036	.019	3	3
BLOOD_Leukemia	CSMD2 →	+1.280	+0.364	.025	.042	3	3
LUNG_SCLC	PDE4DIP →	-2.000	-0.645	.029	.017	3	2
CNS	TP53 →	+0.622	+0.387	.016	.012	3	2
CNS	RYR2 →	+2.622	+0.526	.003	<.001	3	2
LARGE_INTESTINE	CMYA5 →	+1.932	+0.496	.036	.039	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLK_6522 response by MUC5B status — LARGE_INTESTINE

Explore this box plot interactively →