PI3Ka_4409

Across CCLE and GDSC cell-line panels, response to PI3Ka_4409 is significantly associated with the pathway activity of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible PI3Ka_4409 response-associated pathways across cancer lineages are B cell apoptotic process, Locomotory exploration behavior, and Regulation of natural killer cell mediated cytotoxicity, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PI3Ka_4409 response versus B cell apoptotic process pathway activity in LUNG_NSCLC_LUSC (Pearson r = 0.59).

Pathway activity biomarkers of PI3Ka_4409 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	B cell apoptotic process →	+0.291	+0.735	<.001	.009	3	9
URINARY_TRACT	Locomotory exploration behavior →	-0.212	-0.590	.003	.040	2	9
BONE	Regulation of natural killer cell mediated cytotoxicity →	-0.194	-1.157	.004	.006	3	7
PANCREAS	Protein localization to cell junction →	+0.115	+0.604	.003	.004	3	7
OESOPHAGUS	Negative regulation of catecholamine secretion →	-0.919	-0.385	.017	.040	3	7
URINARY_TRACT	Positive regulation of granulocyte differentiation →	+0.199	+0.756	.042	.023	2	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PI3Ka_4409 response vs B cell apoptotic process — LUNG_NSCLC_LUSC

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