PI-103

Across CCLE and GDSC cell-line panels, response to PI-103 is significantly associated with the total protein of multiple proteins, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible PI-103 response-associated proteins across cancer lineages are FRA1, MEK1, and XBP1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PI-103 response versus FRA1 total protein in LUNG_NSCLC_LUAD (Pearson r = 0.34).

Total protein biomarkers of PI-103 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FRA1 →	+0.816	+0.753	.003	.020	3	6
BLOOD_Leukemia	MEK1 →	-0.186	-0.699	.048	.034	3	6
KIDNEY	XBP1 →	+0.414	+1.765	.041	.035	2	7
LUNG_NSCLC_LUSC	Cyclin-E2 →	+0.364	+1.255	.001	.026	3	5
LIVER	14-3-3_beta →	-0.209	-1.478	.049	.044	2	6
LARGE_INTESTINE	Shc_pY317 →	-0.409	-1.581	<.001	<.001	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PI-103 response vs FRA1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →