PI-103

Across CCLE and GDSC cell-line panels, response to PI-103 is significantly associated with the pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible PI-103 response-associated pathways across cancer lineages are Positive regulation of vesicle fusion, Endosome membrane tubulation, and Serotonin metabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PI-103 response versus Positive regulation of vesicle fusion pathway activity in LUNG_SCLC (Pearson r = -0.53).

Pathway activity biomarkers of PI-103 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of vesicle fusion →	-0.127	-0.907	.002	.010	3	8
KIDNEY	Endosome membrane tubulation →	-0.165	-1.755	.016	.048	3	8
STOMACH	Serotonin metabolic process →	-0.226	-1.469	.041	.015	2	9
OESOPHAGUS	Cytolysis in another organism →	-1.238	-1.347	.016	.004	3	8
LARGE_INTESTINE	Regulation of antigen processing and presentation of peptide antigen via MHC class II →	-1.280	-1.113	.001	.004	3	7
OESOPHAGUS	Positive regulation of ruffle assembly →	-0.212	-1.196	.001	.008	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PI-103 response vs Positive regulation of vesicle fusion — LUNG_SCLC

Explore this scatter interactively →