PHA-665752

Across CCLE and GDSC cell-line panels, response to PHA-665752 is significantly associated with the shRNA dependency of multiple gene dependencies, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible PHA-665752 response-associated gene dependencies across cancer lineages are LPAR2, GKAP1, and TAL2, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PHA-665752 response versus LPAR2 shRNA dependency in SKIN (Pearson r = -0.56).

Shrna dependency biomarkers of PHA-665752 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LPAR2 →	-0.226	-0.502	.042	.023	3	4
CNS	GKAP1 →	+0.251	+0.375	.035	.023	3	4
CNS	TAL2 →	+0.313	+0.433	.005	.019	3	4
BLOOD_Leukemia	AKNA →	+0.261	+0.556	.044	.014	2	5
BLOOD_Leukemia	ALOX12 →	+0.262	+0.558	.008	.003	3	4
BLOOD_Lymphoma	H2BC21 →	-0.273	-0.669	.002	.002	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHA-665752 response vs LPAR2 — SKIN

Explore this scatter interactively →