PFI-3

Across CCLE and GDSC cell-line panels, response to PFI-3 is significantly associated with the shRNA dependency of multiple gene dependencies, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible PFI-3 response-associated gene dependencies across cancer lineages are AGRP, HOXB3, and BCL10, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PFI-3 response versus AGRP shRNA dependency in KIDNEY (Pearson r = 0.62).

Shrna dependency biomarkers of PFI-3 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	AGRP →	+0.236	+0.276	<.001	<.001	3	8
SKIN	HOXB3 →	+0.178	+0.506	.022	.039	3	7
BLOOD_Lymphoma	BCL10 →	+0.403	+0.309	.022	.022	3	7
OVARY	MED20 →	+0.288	+0.291	.034	.003	3	6
SKIN	KDM8 →	+0.228	+0.595	.014	.031	3	6
KIDNEY	SPINT2 →	-0.211	-0.288	.004	.033	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFI-3 response vs AGRP — KIDNEY

Explore this scatter interactively →