PFI-1

Across CCLE and GDSC cell-line panels, response to PFI-1 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible PFI-1 response-associated pathways across cancer lineages are Iris morphogenesis, Multivesicular body organization, and Regulation of synaptic plasticity, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PFI-1 response versus Iris morphogenesis shRNA pathway dependency in BLOOD_Myeloma (Pearson r = 0.70).

Shrna pathway dependency biomarkers of PFI-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Iris morphogenesis →	+1.711	+0.409	<.001	.011	3	8
LUNG_NSCLC_LUAD	Multivesicular body organization →	-0.264	-0.586	<.001	.001	3	8
BLOOD_Myeloma	Regulation of synaptic plasticity →	+1.830	+0.754	.002	.002	3	7
SKIN	C21-steroid hormone metabolic process →	+0.930	+0.380	.003	.025	2	8
BLOOD_Myeloma	Membrane fission →	-0.321	-0.537	.041	.006	1	9
LUNG_NSCLC_LUAD	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway →	-0.261	-0.681	.003	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFI-1 response vs Iris morphogenesis — BLOOD_Myeloma

Explore this scatter interactively →