PF-562271

Across CCLE and GDSC cell-line panels, response to PF-562271 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible PF-562271 response-associated pathways across cancer lineages are Neutrophil mediated cytotoxicity, Neutrophil-mediated killing of symbiont cell, and Neutrophil differentiation, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PF-562271 response versus Neutrophil mediated cytotoxicity shRNA pathway dependency in BLOOD_Lymphoma (Pearson r = -0.74).

Shrna pathway dependency biomarkers of PF-562271 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Neutrophil mediated cytotoxicity →	-0.448	-0.700	.038	.011	3	7
BLOOD_Lymphoma	Neutrophil-mediated killing of symbiont cell →	-0.448	-0.700	.038	.011	3	7
BLOOD_Leukemia	Neutrophil differentiation →	+1.041	+0.622	.043	.011	3	7
LIVER	Response to growth hormone →	+1.862	+0.286	<.001	.015	3	7
UPPER_AERODIGESTIVE_TRACT	Vitamin transmembrane transport →	-1.579	-0.543	.004	.011	3	7
BLOOD_Leukemia	Negative regulation of autophagosome maturation →	-1.247	-0.668	.009	.025	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PF-562271 response vs Neutrophil mediated cytotoxicity — BLOOD_Lymphoma

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